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Discussion
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Implication
Clinical review demonstrates widespread prevalence and multisystem impacts of vitamin D deficiency in general populations, highlighting the need for updated prevention and treatment strategies.
Key Points
- Assess the ongoing prevalence of vitamin D deficiency, evaluate its broader impacts on skeletal and nonskeletal organ systems, and outline evidence-based strategies for clinical prevention and treatment.
- Narrative review synthesizing evidence on historical food fortification, global vitamin D status, and associated disease risks.
- Evaluated clinical literature addressing optimal serum levels and therapeutic supplementation regimens across diverse demographics.
- Vitamin D deficiency remains common worldwide despite historical food fortification initiatives that largely eradicated rickets.
- Deficiency negatively affects bone metabolism while also contributing to disease pathways across multiple nonskeletal organ systems.
Cite This Study
Michael F. Holick (2007) studied this question.