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December 13, 2025Scientific ReportsOpen Access

The nephroprotective potential of russelioside B isolated from Caralluma quadrangula in gentamicin-induced acute kidney injury via modulation of SIRT-1 pathway

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Authors

MAMawada Mohamed AliAAAsmaa K. Al‐MokaddemEAEssam Abdel‐Sattar

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Overview

Experiment shows gentamicin-induced acute kidney injury reduced in rats by russelioside B, highlighting its anti-inflammatory actions.

Key Points

  • This research assesses the nephroprotective effect of russelioside B against gentamicin-induced kidney injury.
  • Conducted on twenty male rats divided into four groups
  • Administered russelioside B orally before and during gentamicin treatment
  • Evaluated blood and tissue samples for various parameters including BUN, creatinine, and gene expression
  • RB treatment reduced serum BUN and creatinine levels
  • Increased SOD, SIRT-1, IGF-1, and Bcl2 while decreasing inflammatory markers TNF-α and NF-қB
  • Histopathological changes due to gentamicin were alleviated with RB treatment

Cite This Study

Ali et al. (2025) studied this question.

synapsesocial.com/papers/694018f82d562116f28f5dbfhttps://doi.org/10.1038/s41598-025-29874-7
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