What type of study is this?

This is a Human Clinical Trial study (also classified as: Phase 2).

What question did this study set out to answer?

To evaluate the efficacy and safety of Ribociclib combined with Letrozole in women with recurrent low-grade serous carcinoma.

December 12, 2025Journal of Clinical Oncology

Phase II Trial of Ribociclib Plus Letrozole in Women With Recurrent Low-Grade Serous Carcinoma of the Ovary, Fallopian Tube, or Peritoneum: A GOG Partners Trial (GOG 3026)

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To evaluate the efficacy and safety of Ribociclib combined with Letrozole in women with recurrent low-grade serous carcinoma.
Open-label, single-arm, multicenter phase II trial
Included women with measurable, recurrent low-grade serous carcinoma
Patients received 600 mg Ribociclib daily and 2.5 mg Letrozole daily
Confirmed objective response rate was 30.6% including one complete and 14 partial responses
Median progression-free survival was 14.5 months
Most common adverse event was neutropenia, occurring in 47% of patients

Discussion

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Implication

Phase II trial showed Ribociclib plus Letrozole improved progression-free survival in women with recurrent LGSOC, suggesting a new therapeutic option.

Cite This Study

Slomovitz et al. (2025) studied this question.

synapsesocial.com/papers/694018f82d562116f28f5ef2 https://doi.org/10.1200/jco-25-01348

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Implication

Phase II trial showed Ribociclib plus Letrozole improved progression-free survival in women with recurrent LGSOC, suggesting a new therapeutic option.

Phase II Trial of Ribociclib Plus Letrozole in Women With Recurrent Low-Grade Serous Carcinoma of the Ovary, Fallopian Tube, or Peritoneum: A GOG Partners Trial (GOG 3026)

Key Points

Discussion

Implication

Cite This Study

Phase II Trial of Ribociclib Plus Letrozole in Women With Recurrent Low-Grade Serous Carcinoma of the Ovary, Fallopian Tube, or Peritoneum: A GOG Partners Trial (GOG 3026)

Key Points

Discussion

Implication

Cite This Study

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