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Evaluate the immunogenicity and protective effects of a vaccine combining polysaccharides and proteins against pneumococcal disease.

December 12, 2025Frontiers in ImmunologyOpen Access

Antibodies against polysaccharide type 3 and pneumococcal proteins demonstrate synergistic protective effect in a highly virulent type 3 invasive disease model in mice

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Evaluate the immunogenicity and protective effects of a vaccine combining polysaccharides and proteins against pneumococcal disease.
Developed a highly lethal type 3 pneumococcal invasive disease model in mice,
Assessed a vaccine candidate including SPP2 and CPS3 in rabbits and mice,
Measured antibody responses including Ply-neutralizing and opsonophagocytic antibody responses.
Vaccine elicited high titers of neutralizing antibodies and opsonophagocytic activity against CPS3.
Active and passive immunization with SPP2 and CPS3 provided significant protection against death in mice.
Immunization with either antigen alone did not confer protection, indicating a synergistic effect.

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Vaccines show enhanced immune responses in mice against Streptococcus pneumoniae type 3, suggesting new strategies could improve protection.

Stevenson et al. (2025) studied this question.

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Vaccines show enhanced immune responses in mice against Streptococcus pneumoniae type 3, suggesting new strategies could improve protection.