LINC00659 regulates HSP90-IKKα interaction to activate NF-κB signaling and promote glioma invasion

Lijuan Du; Hui Dong; Shanshan Cai; Tao Lin

doi:10.1080/01616412.2025.2594599

December 12, 2025Neurological Research

LINC00659 regulates HSP90-IKKα interaction to activate NF-κB signaling and promote glioma invasion

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Key Points

This research aims to investigate the role of LINC00659 in glioma progression.
Analyzed the function of LINC00659 in glioma cells
Assessed its impact on cell migration and invasion
Examined the involvement of NF-κB signaling
LINC00659 was identified as a promoter of glioma cell migration and invasion
Activated NF-κB signaling pathway was linked to LINC00659
Enhanced epithelial-mesenchymal transition (EMT) characteristics observed

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Implication

Findings show LINC00659 enhances glioma invasion and cell migration, suggesting a target for malignancy treatment.

Abstract

This study identified LINC00659 as a key promoter of glioma cell migration, invasion, and EMT, suggesting its potential as a target against glioma malignancy.

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Cite This Study

Du et al. (2025) studied this question.

synapsesocial.com/papers/6940190c2d562116f28f6490 https://doi.org/10.1080/01616412.2025.2594599

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LINC00659 regulates HSP90-IKKα interaction to activate NF-κB signaling and promote glioma invasion

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

LINC00659 regulates HSP90-IKKα interaction to activate NF-κB signaling and promote glioma invasion

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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