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December 12, 2025MicroorganismsOpen Access

Unravelling the Genomic and Virulence Diversity of Legionella pneumophila Strains Isolated from Anthropogenic Water Systems

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Authors

SBSofia BarigelliUniversity of Perugia PKPiotr KoperMaria Curie-Skłodowska University MPMaya PetricciuoloUniversity of Perugia

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Implication

Comparative genomics revealed diverse virulence and cytotoxicity in Legionella pneumophila strains from water systems, suggesting varied risk for Legionnaires' disease.

Key Points

The study aims to analyze the genomic and virulence diversity of Legionella pneumophila strains found in anthropogenic water systems.
Environmental surveillance of 50 sites over six years
Isolation and characterization of Legionella pneumophila strains
Cytotoxicity and intracellular replication assessment in THP-1-like macrophages
Phylogenetic analysis using core genome multilocus sequence typing (cgMLST)
Comparative genomics of representative isolates
20 out of 50 monitored sites had Legionella pneumophila contamination.
Identified five serogroups (sg) and 13 Sequence Types (STs).
Strain-dependent differences in cytotoxicity and intracellular replication observed.
Significant pathogenic diversity noted within the same species.
Diversity in virulence repertoire linked to secretion systems like Dot/Icm and Lvh.

Cite This Study

Barigelli et al. (2025) studied this question.

synapsesocial.com/papers/6940190c2d562116f28f64bc https://doi.org/10.3390/microorganisms13122832

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Implication

Comparative genomics revealed diverse virulence and cytotoxicity in Legionella pneumophila strains from water systems, suggesting varied risk for Legionnaires' disease.

Unravelling the Genomic and Virulence Diversity of Legionella pneumophila Strains Isolated from Anthropogenic Water Systems

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Implication

Key Points

Cite This Study

Unravelling the Genomic and Virulence Diversity of Legionella pneumophila Strains Isolated from Anthropogenic Water Systems

Discussion

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Implication

Key Points

Cite This Study

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