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December 12, 2025Blood AdvancesOpen Access

Impact of Age on Graft-vs-Host Disease and Overall Survival in Pediatric Hematopoietic Cell Transplant Recipients

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Authors

MNMiki NishitaniRGRudi-Ann Tamara GrahamTWTao Wang

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Overview

Analysis shows increased incidence of graft-versus-host disease in older pediatric patients, indicating age impacts survival outcomes.

Key Points

  • To compare the incidence of acute and chronic graft-versus-host disease in pediatric patients and evaluate its impact on overall survival and treatment-related mortality.
  • Analysis included 14,099 pediatric hematopoietic cell transplant patients aged ≤21 years from 2002-2020.
  • Patients were categorized by age: 0-2 years, 3-12 years, and 13-21 years.
  • Incidence of acute and chronic graft-versus-host disease was compared among age groups.
  • No difference in grade II-IV and III-IV acute graft-versus-host disease by Day 100 across age groups except for older patients with nonmalignant disease.
  • Incidence of moderate/severe chronic graft-versus-host disease increased with age.
  • Severe acute graft-versus-host disease and moderate/severe chronic graft-versus-host disease were associated with inferior overall survival.

Cite This Study

Nishitani et al. (2025) studied this question.

synapsesocial.com/papers/694019192d562116f28f6603https://doi.org/10.1182/bloodadvances.2025017393
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  1. 1Optimizing Haploidentical Donor Selection for Pediatric Hematopoietic Cell Transplant2026 · 2 citations
  2. 2Retrospective analysis of the incidence and outcome of late acute and chronic graft-versus-host disease—an analysis from transplant centers across Europe2024 · 16 citations
  3. 3Donor and recipient age-related differences in immunological reconstitution affect development of chronic graft-versus-host disease2025
  4. 4SPECIAL CONSIDERATIONS IN THE DIAGNOSIS AND MANAGEMENT OF CHRONIC GRAFT-VERSUS-HOST DISEASE IN PEDIATRIC PATIENTS2025
  5. 5Impact of donor age on transplant outcomes in unrelated allogeneic hematopoietic stem cell transplantation using post-transplant cyclophosphamide-based gvhd prophylaxis2025