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December 12, 2025Chemistry & BiodiversityOpen Access

Antibacterial and Antibiotic Potentiation Activities of Selected Australian Terminalia spp. Against Gastrointestinal Pathogens

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Authors

MZMuhammad Jawad Yousaf ZaiGriffith UniversityMCMatthew James CheesmanGriffith UniversityICIan Edwin CockGriffith University

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Implication

This study demonstrates antibacterial activity of Terminalia extracts in inhibiting infections, suggesting potential for treatment.

Key Points

  • To evaluate the antibacterial and antibiotic potentiation activities of selected Australian Terminalia spp. against gastrointestinal pathogens.
  • Screening of Terminalia spp. leaf extracts against gastrointestinal pathogens.
  • Utilization of solvents with different polarities for extraction of phytoconstituents.
  • Assessment of extracts for antibacterial activity and toxicity in human dermal fibroblast cell lines.
  • T. canescens methanol extract exhibited significant activity against A. hydrophila and B. cereus at 960 µg/mL.
  • Ethyl acetate extracts showed no antibacterial activity.
  • Terminalia extracts combined with antibiotics resulted in various interactions, including synergistic and antagonistic.

Cite This Study

Zai et al. (2025) studied this question.

synapsesocial.com/papers/694019222d562116f28f692fhttps://doi.org/10.1002/cbdv.202502455
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Selected Australian Terminalia Species Extracts Inhibit β-Lactam Drug-Resistant Bacteria Growth and Potentiate the Activity of Conventional Antibiotics: Bioactivities and Phytochemistry2024 · 7 citations
  2. 2Combinations of Terminalia bellirica (Gaertn.) Roxb. and Terminalia chebula Retz. Extracts with Selected Antibiotics Against Antibiotic-Resistant Bacteria: Bioactivity and Phytochemistry2024 · 2 citations
  3. 3Flavonoids identified in Australian Terminalia inhibit methicillin and β-lactam-resistant pathogens, exhibit efflux pump inhibitory activity, and potentiate conventional antibiotics2026
  4. 4Antioxidant and Antimicrobial Activities of Terminalia laxiflora Engl. and Terminalia myriocarpa Van Heurck & Müll. Arg. Leaves in Relation to Their GC-MS and UPLC-ESI-MS Metabolite Profiling2024 · 1 citations
  5. 5Preliminary Phytochemical Screening, GC-MS analysis and Comparative In- Vitro Antibacterial Evaluation of Three Terminalia Species (T. alata, T. arjuna, and T. bellirica) from the Eastern Ghats, India2026