Cohort study shows elevated kynurenine increases sarcopenia risk in older adults, suggesting its role as a biomarker.
These findings extend previous experimental evidence to the clinical setting, suggesting that elevated kynurenine-driven by IDO1 activity-contributes to sarcopenia in older adults. Circulating kynurenine may serve as an exploratory biomarker candidate for identifying individuals at heightened risk for muscle deterioration, warranting further validation in future studies.
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Kim et al. (2025) studied this question.
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