This study demonstrates how EHV-1 infection impacts cytoskeleton dynamics in murine astrocytes, suggesting replication is limited under certain conditions.
Equid alphaherpesvirus type 1 (EHV-1) is a neurotropic virus known to manipulate host cytoskeletal structures to facilitate infection and spread. In this study, we examined the susceptibility of primary murine astrocytes to neuropathogenic and non-neuropathogenic EHV-1 strains, focusing on the role of the actin and microtubule cytoskeleton. Infection induces morphological changes and remodeling of actin and microtubule networks. Viral antigen was localized along actin filaments and microtubules, indicating their likely role in intracellular viral trafficking. Cytoskeletal inhibitors significantly reduced viral DNA levels. Both EHV-1 strains exhibited limited replication, suggesting that EHV-1 may establish abortive infection in murine astrocytes.
No takes yet. Share an insight, caveat, or question.
Słońska et al. (2025) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: