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This research aims to explore the neurovascular degeneration characteristics in diabetic retinopathy.

December 11, 2025Scientific ReportsOpen Access

Integrative severity scale for diabetic macular atrophy and ischemia using structural OCT and OCT angiography

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Clustering reveals distinct groups in diabetic retinopathy, indicating links to macular atrophy and visual acuity.

This research aims to explore the neurovascular degeneration characteristics in diabetic retinopathy.
Analyzed 327 DR eyes without macular edema using optical coherence tomography (OCT) and OCT angiography (OCTA).
Defined nonperfusion squares (NPSs) based on vascular signal absence.
Employed clustering techniques to classify severity groups: Mild, Intermediate, and Severe.
Eyes with diabetic macular atrophy in the Severe group had higher NPS counts and worse visual acuity.
A significant negative correlation was found between central subfield thickness and superficial NPS counts (ρ = - 0.252, P = 0.039).
Findings suggest a link between macular ischemia and retinal atrophy.

Yoshida et al. (2025) studied this question.

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