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December 11, 2025Frontiers in Aging NeuroscienceOpen Access

Associations between the red blood cell distribution width and 30-day mortality in critically ill patients with delirium: a retrospective study using the MIMIC-IV database

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Authors

SMShulan MaLLLin LinSZShuwen Zheng

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Overview

Retrospective study reveals that higher red blood cell distribution width is linked to increased 30-day mortality in critically ill patients with delirium, indicating a need for careful monitoring.

Key Points

  • The aim is to investigate the association between red blood cell distribution width and 30-day mortality in critically ill patients with delirium.
  • Analyzed data from the MIMIC-IV database; a retrospective cohort study
  • Identified delirium using the Confusion Assessment Method for the Intensive Care Unit
  • Evaluated the association using multivariable Cox regression analysis
  • Conducted subgroup analyses of various comorbidities
  • Increased RDW correlated with higher 30-day mortality risk (Hazard Ratio 1.04)
  • Middle and high RDW groups had significantly higher mortality risks (HRs 1.54 and 2.25)
  • Subgroup analyses confirmed elevated mortality rates associated with higher RDW
  • Linear relationships between RDW and mortality were demonstrated via restricted cubic spline analysis

Cite This Study

Ma et al. (2025) studied this question.

synapsesocial.com/papers/6940192a2d562116f28f6c7dhttps://doi.org/10.3389/fnagi.2025.1599858
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