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December 11, 2025Frontiers in Cellular and Infection MicrobiologyOpen Access

Deciphering the population dynamics and drug-resistance characteristics of extrapulmonary tuberculosis: genomic and clinical insights from a Chinese hospital

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Authors

SGShiwei GongXLX.Y. LiYRYouyi Rao

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Overview

Analysis reveals drug resistance trends in extrapulmonary tuberculosis, suggesting significant clinical concerns.

Key Points

  • To examine the prevalence and drug resistance characteristics of extrapulmonary tuberculosis in a clinical setting.
  • Analyzed 427 isolates of extrapulmonary tuberculosis from a Chinese hospital.
  • Conducted drug susceptibility testing for anti-TB drugs.
  • Performed whole-genome sequencing for resistance characterization and phylogenetic analysis.
  • Utilized chi-square analysis for evaluating clinical characteristics and drug resistance patterns.
  • Upward trend in EPTB strains, with predominant types being urinary system, meningitis, and lymph node tuberculosis.
  • Lineage 2 was prevalent in 83.60% of isolates, linked to resistance against isoniazid and streptomycin.
  • Overall resistance rates were 13.58% for isoniazid and 7.73% for rifampicin.
  • Common mutations contributing to resistance were identified in specific genes, including katG and rpoB.
  • Clustering rate was 19.67%, indicating limited recent transmission.

Cite This Study

Gong et al. (2025) studied this question.

synapsesocial.com/papers/6940192a2d562116f28f6cafhttps://doi.org/10.3389/fcimb.2025.1692783
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Genomic insights into extrapulmonary tuberculosis reveal enrichment of lineage 2 with high drug resistance in specific clinical phenotypes2025
  2. 2Whole-genome sequencing-based genetic diversity, transmission dynamics, and drug-resistant mutations in Mycobacterium tuberculosis isolated from extrapulmonary tuberculosis patients in western Ethiopia2024 · 4 citations
  3. 3Phenotypic drug resistance and genome sequencing based identified mutations linked to resistance in Mycobacterium tuberculosis isolated from extrapulmonary clinical specimens2026
  4. 4Detection of Mycobacterium Tuberculosis in Extrapulmonary Specimens and Drug Sensitivity Pattern in a Tertiary Level Chest Disease Hospital of Bangladesh2025
  5. 5Analysis of epidemiological characteristics of extrapulmonary tuberculosis from South-Central China2024 · 2 citations