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August 5, 2025Open Access

Genomic insights into extrapulmonary tuberculosis reveal enrichment of lineage 2 with high drug resistance in specific clinical phenotypes

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Authors

KSKusum SharmaABAveg BhandariGMGowrang Kasaba Manjunath

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Overview

Whole genome sequencing reveals lineage 2 has high drug resistance in extrapulmonary tuberculosis, suggesting avenues for personalized treatment.

Key Points

  • Lineage 2 exhibited the highest level of drug resistance at 54.1% among isolates studied.
  • Whole genome sequencing detected 29.9% resistance, exceeding the 23.9% found through phenotypic testing.
  • Mixed infections occurred in 6.8% of isolates, with heteroresistance being more common in these cases.
  • Findings support the use of genomic sequencing for timely, personalized treatment approaches in extrapulmonary tuberculosis.

Cite This Study

Sharma et al. (2025) studied this question.

synapsesocial.com/papers/689523d29f4f1c896c42a0c8https://doi.org/10.1101/2025.08.05.25332932
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