What question did this study set out to answer?

This research aims to explore brain metabolic connectivity in ALS patients with the C9ORF72 expansion compared to controls.

December 11, 2025European Journal of Nuclear Medicine and Molecular ImagingOpen Access

Brain metabolic connectivity in ALS due to C9ORF72 hexanucleotide expansion: a 18FFDG-PET study

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Authors

ACAntonio CanosaAmyotrophic Lateral Sclerosis Association SCStefano CallegaroUniversity of Padua UMUmberto ManeraAmyotrophic Lateral Sclerosis Association

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Implication

Brain metabolic connectivity shows hypometabolism in thalamus and hypermetabolism in cerebellum among C9-ALS, implying altered salience network engagement.

Key Points

This research aims to explore brain metabolic connectivity in ALS patients with the C9ORF72 expansion compared to controls.
Used [18F]FDG-PET to assess brain metabolism in C9-ALS and ctrl-ALS groups.
Applied a two-sample t-test model using SPM12 to compare metabolic activity between groups.
Conducted interregional correlation analysis (IRCA) based on significant metabolic clusters.
C9-ALS exhibited hypometabolism in the thalamus and hypermetabolism in the cerebellum and brainstem compared to ctrl-ALS.
Positive correlation between thalamic seed and cingulate cortex was stronger in C9-ALS than in ctrl-ALS.
C9-ALS showed negative correlation between thalamic region and sensorimotor cortex, unlike ctrl-ALS.

Cite This Study

Canosa et al. (2025) studied this question.

synapsesocial.com/papers/694019342d562116f28f6d86 https://doi.org/10.1007/s00259-025-07705-1

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Implication

Brain metabolic connectivity shows hypometabolism in thalamus and hypermetabolism in cerebellum among C9-ALS, implying altered salience network engagement.

Brain metabolic connectivity in ALS due to C9ORF72 hexanucleotide expansion: a 18FFDG-PET study

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Implication

Key Points

Cite This Study

Brain metabolic connectivity in ALS due to C9ORF72 hexanucleotide expansion: a 18FFDG-PET study

Discussion

Member takes

Implication

Key Points

Cite This Study

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