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December 11, 2025Journal of Osteopathic MedicineOpen Access

Analysis of hepatitis B immunity in vaccinated medical students

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Authors

NGNicole GentileCAChandni AgheraHSH. E. Smith

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Overview

Retrospective cohort study shows decreasing antibody titer in vaccinated students from 2011 to 2023, indicating need for booster vaccinations.

Key Points

  • This study aims to evaluate factors affecting hepatitis B immunity in vaccinated medical students.
  • Retrospective cohort study of vaccination data from medical students at VCOM-Carolinas from 2011 to 2023.
  • Assessment of age, sex, vaccination dates, and immunity status based on antibody titers.
  • Statistical analysis included Wilcoxon rank-sum test and multivariable logistic regression.
  • Significant increase in nonimmunity rates from 16.0% to 61.3% over the study period (p<0.001).
  • Nonimmunity was significantly related to age at first vaccination (47.8% nonimmune if vaccinated at ≤5 years vs. 11.3% if vaccinated after).
  • The odds of nonimmunity increased by 1.11 for each year postimmunization (p<0.001).

Cite This Study

Gentile et al. (2025) studied this question.

synapsesocial.com/papers/694019342d562116f28f6e91https://doi.org/10.1515/jom-2025-0005
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Hepatitis B Immunization Among Healthcare Students: A Narrative Review of Occupational Risk, Seroprotection, and Immunization Management2026
  2. 2Effectiveness of Stepwise Hepatitis B Revaccination According to Vaccination History in Healthcare Students: a Retrospective Observational Study.2026 · 1 citations
  3. 3Hepatitis-B immune status and vaccination in Family Medicine Practice: A retrospective study2024
  4. 4Hepatitis B vaccine immunity in healthcare workers: Seroprotection and cellular immune signatures of waning response2026
  5. 5Hepatitis B awareness among medical students and their vaccination status2024