Pharmacovigilance analysis shows arrhythmias and cardiomyopathy risks linked to antifungal agents, indicating the need for awareness.
These findings highlight that azoles and polyenes show substantial associations with CAEs, particularly for TdP/QTP and arrhythmias. Itraconazole showed a significant association with cardiac failure and cardiomyopathy, while the signal for isavuconazole was weaker than for other triazoles. No significant cardiotoxicity signals were detected for echinocandins.
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Cao et al. (2025) studied this question.
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