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December 11, 2025Diseases of the Colon & Rectum

Impact of Obesity on Postoperative Outcomes in Transanal Total Mesorectal Excision for Rectal Cancer

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Authors

MZMakda ZewdeIcahn School of Medicine at Mount SinaiDPDaniel PeyserIcahn School of Medicine at Mount SinaiAYAllen T. YuUniversity of Arizona

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Overview

Retrospective cohort study compares postoperative outcomes in obese and non-obese patients undergoing transanal total mesorectal excision for rectal cancer, indicating similar morbidity rates.

Key Points

  • To compare postoperative and oncologic outcomes of transanal total mesorectal excision in obese and non-obese patients.
  • Retrospective cohort study across eight tertiary centers in the United States.
  • Eligible patients underwent transanal total mesorectal excision for rectal adenocarcinoma between 2011 and 2020.
  • Analysis of intraoperative complications, 30-day postoperative complications, local and distant recurrence, overall and disease-free survival.
  • 390 procedures were performed, with 271 non-obese and 120 obese patients.
  • Operative time was longer in the obese group; no differences in conversion rates or intraoperative complications.
  • No significant differences in postoperative complications or mid-term oncologic outcomes, but obese patients had lower distant recurrence rates.

Cite This Study

Zewde et al. (2025) studied this question.

synapsesocial.com/papers/69401b172d562116f28f7358https://doi.org/10.1097/dcr.0000000000004090
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Utility of Transanal Total Mesorectal Excision in Patients With Obesity and Mid-to-Low Rectal Cancer: A Single-Center, Retrospective Cohort Study2026 · 1 citations
  2. 2Transanal <i>versus</i> transabdominal total mesorectal excision for rectal cancer in minimally invasive surgery: meta-analysis2025
  3. 3Transanal versus robotic total mesorectal excision for mid- and low-rectal cancer: A single-center comparative cohort of 109 patients2026 · 1 citations
  4. 4Comparison of short- and long-term outcomes among laparoscopic, robotic-assisted, and transanal total mesorectal excision procedures in patients with rectal cancer: a propensity score-matching analysis2025 · 4 citations
  5. 5Robotic, transanal, and laparoscopic total mesorectal excision for locally advanced mid/low rectal cancer: European multicentre, propensity score-matched study2024 · 31 citations