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December 11, 2025PathogensOpen Access

Genomic Insights into Pasteurella multocida Serotype B:2 from Hemorrhagic Septicemia Outbreaks in Wildlife and Livestock in Kazakhstan

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Authors

АААсылулан АмиргазинGYGulzhan YessembekovaAAAssel Akhmetova

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Overview

Genomic analysis shows virulence gene patterns among livestock and wildlife, suggesting implications for managing outbreaks.

Key Points

  • The research aimed to analyze the genomes of Pasteurella multocida associated with hemorrhagic septicemia in Kazakhstan.
  • Conducted whole-genome sequencing on 22 P. multocida isolates from saigas and livestock.
  • Performed comparative genomic analysis with publicly available genomes.
  • Examined phylogenetic clustering related to outbreaks and identified mutations in virulence genes.
  • Isolates belonged to the B:2:ST122 genotype and formed distinct phylogenetic clusters.
  • Identified a deletion of the flp1 gene linked to virulence in isolates from the 2015 saiga mortality event.
  • Revealed low virulence gene diversity and an open pangenome in P. multocida B:L2:ST122 genomes.

Cite This Study

Амиргазин et al. (2025) studied this question.

synapsesocial.com/papers/69401b172d562116f28f73b2https://doi.org/10.3390/pathogens14121273
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