Cobalt-catalyzed synthesis of α-quaternary aliphatic nitriles, demonstrating good yields and a proposed mechanism.
Herein, we developed a cobalt-catalyzed three-component strategy to synthesize α-quaternary aliphatic nitriles in good yields. This protocol proceeds through the sequential addition of indoles, dienes, and N-cyanosuccinimide. The scope of this method has been extensively explored with various substituted N-pyrimidyl-indoles. Terminally substituted diene and 1,2-disubstituted diene also participated in the reaction. Notably, N-pyridyl-2-pyridones are also compatible with this protocol. The synthesized nitrile product was further converted into a tetrazole derivative. A plausible reaction mechanism is proposed to account for the present transformation.
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Prusty et al. (2025) studied this question.
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