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The research aims to elucidate how ATP influences UvrA's ability to recognize DNA damage during the repair process.

December 11, 2025Nature CommunicationsOpen Access

Structural snapshots of the mechanism of ATP-dependent DNA damage recognition by UvrA

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Cryo-electron microscopy shows UvrA's conformational changes in DNA damage detection, indicating a crucial role of ATP.

The research aims to elucidate how ATP influences UvrA's ability to recognize DNA damage during the repair process.
Utilized cryo-electron microscopy to capture structural snapshots of UvrA complexed with different DNAs.
Examined UvrA in the presence and absence of nucleotides to assess its ATP-binding function.
Analyzed the dimeric formation of UvrA and its interaction with UvrB in DNA repair.
Revealed significant rearrangement of the UvrA dimer upon ATP binding.
Demonstrated the role of UvrA in mechanically probing DNA integrity for damage localization.
Provided structural insights into the UvrA:UvrB:DNA complex.

Nirwal et al. (2025) studied this question.

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