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This research investigates how the locus coeruleus influences nociceptive sensitization through its projections to the thalamus and anterior cingulate cortex.

December 11, 2025AnesthesiologyOpen Access

Modulation of pain sensitivity by the locus coeruleus–paraventricular thalamic nucleus–anterior cingulate cortex pathway in mice

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Authors

SKShihui Kuai ZLZijie Li ZWZiyi Wu

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Overview

Optogenetic manipulation enhances nociceptive sensitization in mice, indicating a key role for the locus coeruleus pathway.

Key Points

This research investigates how the locus coeruleus influences nociceptive sensitization through its projections to the thalamus and anterior cingulate cortex.
Used complete Freund’s adjuvant to induce pain-like behaviors in adult male and female mice.
Combined Fos-TRAP, in vivo recordings, and viral tracing to examine functional connectivity.
Utilized optogenetic and chemogenetic tools to manipulate LC projections and measure effects on pain behaviors.
CFA exposure elevated c-Fos expression across LC, PVA, and ACC, indicating increased neural activity.
LC–PVA–ACC circuits showed greater ACC firing rates under inflammatory conditions compared to direct LC–ACC activation.
Manipulation of LC–PVA–ACC circuits resulted in stronger modulation of pain sensitivity than LC–ACC stimulation.

Cite This Study

Kuai et al. (2025) studied this question.

synapsesocial.com/papers/69401b1e2d562116f28f7643 https://doi.org/10.1097/aln.0000000000005897

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December 11, 2025AnesthesiologyOpen Access

Modulation of pain sensitivity by the locus coeruleus–paraventricular thalamic nucleus–anterior cingulate cortex pathway in mice

View Full Paper

Ask AI

Bookmark

Authors

SKShihui Kuai ZLZijie Li ZWZiyi Wu

Discussion

Member takes

Overview

Optogenetic manipulation enhances nociceptive sensitization in mice, indicating a key role for the locus coeruleus pathway.

Key Points

This research investigates how the locus coeruleus influences nociceptive sensitization through its projections to the thalamus and anterior cingulate cortex.
Used complete Freund’s adjuvant to induce pain-like behaviors in adult male and female mice.
Combined Fos-TRAP, in vivo recordings, and viral tracing to examine functional connectivity.
Utilized optogenetic and chemogenetic tools to manipulate LC projections and measure effects on pain behaviors.
CFA exposure elevated c-Fos expression across LC, PVA, and ACC, indicating increased neural activity.
LC–PVA–ACC circuits showed greater ACC firing rates under inflammatory conditions compared to direct LC–ACC activation.
Manipulation of LC–PVA–ACC circuits resulted in stronger modulation of pain sensitivity than LC–ACC stimulation.

Cite This Study

Kuai et al. (2025) studied this question.

synapsesocial.com/papers/69401b1e2d562116f28f7643 https://doi.org/10.1097/aln.0000000000005897

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