What type of study is this?

This is a Human Clinical Trial study.

What question did this study set out to answer?

This research aims to assess the effects of clobetasol propionate on cortisol levels and growth velocity in children with atopic dermatitis.

December 11, 2025DermatologyOpen Access

Evaluation of the effect of clobetasol propionate on circulating cortisol and growth velocity in children with atopic dermatitis: a modelling and simulation study

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Authors

JDJanna K. DuongAustro Control (Austria)SDSven C. van DijkmanLeiden University GOG B OngCenter for Global Development

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Implication

Modelling study shows clobetasol propionate affects cortisol and growth velocity in children with atopic dermatitis, suggesting safe application limits.

Key Points

This research aims to assess the effects of clobetasol propionate on cortisol levels and growth velocity in children with atopic dermatitis.
Utilized physiologically-based pharmacokinetic and pharmacokinetic-pharmacodynamic modelling to simulate dermal absorption of clobetasol propionate.
Created virtual cohort of paediatric patients aged 1 to <18 years.
Evaluated impact of varying treatment conditions on systemic exposure to clobetasol propionate, cortisol levels, and growth velocity.
Surface area significantly influences local and systemic concentrations of clobetasol propionate.
Short-term use of clobetasol propionate cream did not affect growth velocity in children with atopic dermatitis.
Clobetasol propionate can be safely applied on up to 20% of body surface area without clinically relevant changes to cortisol levels.

Cite This Study

Duong et al. (2025) studied this question.

synapsesocial.com/papers/69401b262d562116f28f78b8 https://doi.org/10.1159/000549781

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Implication

Modelling study shows clobetasol propionate affects cortisol and growth velocity in children with atopic dermatitis, suggesting safe application limits.

Evaluation of the effect of clobetasol propionate on circulating cortisol and growth velocity in children with atopic dermatitis: a modelling and simulation study

Discussion

Member takes

Implication

Key Points

Cite This Study

Evaluation of the effect of clobetasol propionate on circulating cortisol and growth velocity in children with atopic dermatitis: a modelling and simulation study

Discussion

Member takes

Implication

Key Points

Cite This Study

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