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December 11, 2025Digestive DiseasesOpen Access

Physical activity is inversely associated with clinical exacerbation in patients with Crohn's disease in remission - a prospective cohort study

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Authors

CSChen Sarbagili‐ShabatSZShira Zelber‐SagiNINaomi Fliss Isakov

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Overview

Prospective cohort study shows that physical activity reduces relapse risk in Crohn's disease patients, indicating better quality of life outcomes.

Key Points

  • To evaluate the relationship between physical activity and relapse incidence in Crohn's disease patients in remission and its links to patient-reported outcomes.
  • Prospective cohort study of 106 adult patients with Crohn's disease in clinical remission.
  • Participants assessed at baseline using questionnaires on physical activity and nutrition alongside outcome measures.
  • Follow-up assessments for one year or until clinical relapse, with analyses using multivariable Cox proportional hazards models adjusted for confounders.
  • 23 patients (21.7%) experienced clinical relapse during follow-up.
  • Physical activity at least twice weekly associated with a reduced relapse risk (HR=0.26).
  • Aerobic activity linked to lower relapse risk (HR=0.31).
  • High-resistance physical activity correlated with improved quality of life measures like pain interference and sleep disturbance.

Cite This Study

Sarbagili‐Shabat et al. (2025) studied this question.

synapsesocial.com/papers/69401b262d562116f28f7908https://doi.org/10.1159/000550048
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Association of Recreational Physical Activity with Gut Microbiota Diversity and Composition, and Symptom Burden in Crohn’s Disease: A Cross-Sectional Study2025
  2. 2The Impact of Physical Activity on the Clinical Course of Crohn's Disease2025
  3. 3Physical Activity Levels and Social Cognitive Theory Correlates among Adults with Crohn’s Disease: Preliminary Results from a Cross-Sectional Analysis2024 · 1 citations
  4. 4Objective assessment of physical activity using wearable devices in patients with mild-to-moderate Crohn’s disease2026
  5. 5The Impact of Aerobic Exercise on a Novice Athlete with Crohn's Disease: A Case Study from Greece2024