Observations reveal distinct microbiome profiles linked to mucosal barrier dysfunction in laryngopharyngeal reflux.
Our findings demonstrate that LPR is associated with both distinct salivary microbial profiles and disruption of the pre-epithelial mucosal barrier constituents. These observations support a potential role for salivary microbiota dysbiosis in the pathogenesis of LPR, highlighting a novel interconnection between microbial community perturbations and mucosal barrier dysfunction in this disease. LEVEL OF EVIDENCE：: 4 TRIAL REGISTRATION: No. ChiCTR2400091947. Registered on November 6,2024 retrospectively.
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