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This research aims to understand the roles of TFEB and TFE3 in viral infection and lysosomal function.

December 10, 2025Frontiers in MicrobiologyOpen Access

Modulation of viral replication, autophagy and apoptosis by induction and mutual regulation of transcription factors EB and E3 during coronavirus infection

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Infection with coronaviruses alters autophagy and apoptosis in cells, indicating new targets for treatment.

This research aims to understand the roles of TFEB and TFE3 in viral infection and lysosomal function.
Examined the expression of TFEB and TFE3 during coronavirus infections in cell and chicken models.
Utilized TFE3 knockdown to explore its role in viral replication and cell death.
Inhibited lysosomal pathway with brefeldin A (BFA) to evaluate its effect on virus release.
TFEB and TFE3 expression is upregulated during infections of IBV, HCoV-OC43, and PEDV.
TFE3 was found to significantly influence viral replication and apoptosis when knocked down.
BFA treatment revealed that HCoV-OC43 is released primarily via the lysosomal pathway.

Yang et al. (2025) studied this question.

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