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December 10, 2025Frontiers in MedicineOpen Access

Impact of anti-VEGF therapy on choroidal thickness in patients with retinal vein occlusion: a systematic review and meta-analysis

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Authors

XCXianglin ChengXZXinwei ZengSLShimei Liu

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Overview

Systematic review shows anti-VEGF therapy reduces choroidal thickness in retinal vein occlusion, suggesting variable outcomes with different agents.

Key Points

  • To review changes in choroidal thickness following anti-VEGF treatment in retinal vein occlusion patients.
  • Systematic literature search identified 16 eligible studies.
  • Included a total of 545 patients and 547 eyes.
  • Data extraction focused on subfoveal choroidal thickness at multiple follow-up intervals.
  • Meta-analyses assessed pooled changes in choroidal thickness and subgroup analyses based on drug type.
  • At 1 and 3 months, significant reductions in choroidal thickness were observed with anti-VEGF therapy.
  • Choroidal thickness tended to return toward baseline by 12 months.
  • Subgroup analyses indicated variable effects among anti-VEGF agents, with ranibizumab and aflibercept showing early reductions.
  • Branch retinal vein occlusion patients had significant reductions at 1 month, unlike central retinal vein occlusion patients.

Cite This Study

Cheng et al. (2025) studied this question.

synapsesocial.com/papers/69401b312d562116f28f7afahttps://doi.org/10.3389/fmed.2025.1663350
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Investigation of choroidal structure changes after intravitreal anti-VEGF therapy for retinal vein occlusion2024
  2. 2Characteristics of macular edema associated with retinal vein occlusion showing poor anatomic response to three loading anti-vascular endothelial growth factor injections: an optical coherence tomography analysis2024 · 12 citations
  3. 3Changes of Optical Coherence Tomography Biomarkers in Macular Edema Secondary to Retinal Vein Occlusion After Anti-VEGF and Anti-Inflammatory Therapies2022 · 17 citations
  4. 4Peripapillary and Subfoveal Choroidal Thickness in Retinal Vein Occlusions2022 · 12 citations