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Evaluate the role of leukemic stem cells in acute myeloid leukemia (AML) and the challenges in their detection.

December 10, 2025Frontiers in PharmacologyOpen Access

Flow cytometric detection of leukemic stem cells in Acute Myeloid Leukemia: current status and future directions

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Evaluate the role of leukemic stem cells in acute myeloid leukemia (AML) and the challenges in their detection.
Reviewed current flow cytometry (FC) techniques for detecting leukemic stem cells (LSCs) in AML.
Discussed immunophenotypic variability and standardization issues in FC panels.
Highlighted recent clinical studies assessing LSC detection and its implications for measurable residual disease.
Therapeutic resistance associated with leukemic stem cells contributes to MRD negativity in some AML patients.
Current FC methods show limited sensitivity in detecting LSCs due to immunophenotypic diversity.
Advances in spectral flow cytometry may enhance detection capabilities for LSCs.

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Clinical studies reveal challenges in detecting leukemic stem cells, highlighting the role of therapeutic resistance in AML prognosis.

Youssef et al. (2025) studied this question.

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