Biconcave vertebral fractures as a possible distinctive feature of indolent systemic mastocytosis compared with primary osteoporosis

Gaetano Paride Arcidiacono; Marco Onofrio Torres; Francesca Zanchetta; Sofia Testoni; Giovanni Tripepi; Alberta Cecchinato; Martin Diogo; Mor Peleg Falb; Francesca Guidolin; Irene Bertozzi; Marco Pizzi; Mauro Cancian; Riccardo Senter; Ilaria Gianesello; Francesca Caroppo; Ilaria Tanasi; Roberta Zanotti; Lorenza Belletti; Maria Fusaro; Elena Campello; Stefania Sella; Paolo Simioni; Sandro Giannini

doi:10.1007/s00198-025-07799-1

Key Points

To identify biconcave vertebral fractures as a feature of indolent systemic mastocytosis and differentiate it from primary osteoporosis.
Compared fracture morphology in indolent systemic mastocytosis and primary osteoporosis.
Used imaging assessments to evaluate vertebral fractures.
Analyzed associations between multiple biconcave vertebral fractures and systemic mastocytosis.
Multiple biconcave vertebral fractures are significantly associated with indolent systemic mastocytosis.
Fracture morphology assessment could reduce diagnostic delays.
Fracture characteristics can guide management strategies for patients with vertebral fragility fractures.

Implication

Observations show biconcave vertebral fractures in indolent systemic mastocytosis, suggesting a diagnostic tool to improve management of fragility fractures.

Abstract

Multiple biconcave VFx are significantly associated with ISM and may help differentiate it from primary OP. Assessment of fracture morphology could reduce diagnostic delay and guide appropriate management in patients with vertebral fragility fractures.

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Cite This Study

Arcidiacono et al. (2025) studied this question.

synapsesocial.com/papers/69401b312d562116f28f7cea https://doi.org/10.1007/s00198-025-07799-1

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Biconcave vertebral fractures as a possible distinctive feature of indolent systemic mastocytosis compared with primary osteoporosis

Key Points

Implication

Abstract

Discussion

Cite This Study

Biconcave vertebral fractures as a possible distinctive feature of indolent systemic mastocytosis compared with primary osteoporosis

Key Points

Implication

Abstract

Discussion

Cite This Study

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