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December 10, 2025CancersOpen Access

Correction: Han et al. Enhanced De Novo Lipid Synthesis Mediated by FASN Induces Chemoresistance in Colorectal Cancer. Cancers 2023, 15, 562

Lingyu Han Weixing Dai Wenqin Luo Ye Li Hongsheng Fang Shaobo Mo Qingguo Li Ye Xu Renjie Wang Guoxiang Cai

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Key Points

Chemoresistance increases in colorectal cancer with enhanced lipid synthesis, indicating a potential area for intervention.
The finding highlights the importance of lipid metabolism in treatment outcomes for colorectal cancer patients.
Assessment using cellular models to explore the role of FASN in lipid synthesis and resistance to chemotherapy enhances understanding.
The implications of metabolic adaptation in cancer therapy call for further studies on lipid targeting strategies.

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Implication

Observational analysis shows lipid synthesis increases chemoresistance in colorectal cancer, suggesting new therapeutic targets.

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Cite This Study

Han et al. (2025) studied this question.

synapsesocial.com/papers/69401b3d2d562116f28f80b5 https://doi.org/10.3390/cancers17243941

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Abstract 7109: Fasn inhibition enhances the efficacy of chemotherapy by inhibiting DNA damage response in colorectal cancer2024
2Increased expression of fatty acid synthase provides a survival advantage to colorectal cancer cells via upregulation of cellular respirationOriginal Research · 2015 · 153 citations
3FASN Inhibition Enhances the Efficacy of Chemotherapy in Colorectal Cancer by Inhibiting the DNA Damage ResponseOriginal Research · 2026 · 5 citations
4Abstract 4760: Inhibition of FASN postpones development of resistance to BRAF inhibitors in colorectal cancer2024
5Abstract 162: Fatty acid synthesis blockade synergizes with immune checkpoint blockade by repolarizing macrophages and enhancing anti-tumor cytotoxicity in gastric cancer2024

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