SIRT3 deficiency exacerbates cognitive decline in D-galactose-induced mice, suggesting a need for therapeutic strategies targeting mitochondrial redox balance.
SIRT3 is a critical regulator of hippocampal mitochondrial redox homeostasis. Augmenting hippocampal SIRT3 represents a promising therapeutic strategy for age-related cognitive impairment, supporting the translation of these findings to clinical interventions for neurological decline.
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An et al. (2025) studied this question.
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