Complex cryogels enhance elasticity and sorption properties in poly(vinyl alcohol), suggesting improved drug delivery.
Complex cryogels were prepared via cryotropic gelation from solutions of poly(vinyl alcohol) (PVA) and polylactide (D,L‐PLA and L‐PLA) blends in a common organic solvent. Subsequent hydration replaced the organic solvent with water, resulting in the coagulation of polylactide and the formation of its particles, which acted as dispersed fillers within the volume of composite PVA cryogels. Investigation of the physicomechanical and diffusion properties, as well as the microstructure of these composites, revealed that increasing the polylactide concentration in the initial polymer solution enhances the elasticity of the resulting composite cryogels. Furthermore, the presence of polylactide particles enables reversible sorption of molecules of a model drug (ibuprofen sodium salt), thereby slowing their release from the composite gel materials compared to unfilled PVA cryogels.
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Michurov et al. (2025) studied this question.
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