What question did this study set out to answer?

To evaluate the feasibility and effects of universal germline testing on access and outcomes for underserved patients with young-onset GI malignancies.

December 10, 2025Clinical Cancer Research

Abstract B025: Universal Germline Testing in Young-Onset GI Malignancies: Expanding Access for Underserved Patients

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Authors

KLKaysia LudfordThe University of Texas MD Anderson Cancer Center YAYsaith Orellana AscencioThe University of Texas Health Science Center at Houston HMHilary MaThe University of Texas MD Anderson Cancer Center

Discussion

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Implication

Pilot study shows universal germline testing increases knowledge and reduces stress in underserved young-onset GI cancer patients.

Key Points

To evaluate the feasibility and effects of universal germline testing on access and outcomes for underserved patients with young-onset GI malignancies.
Pilot study involving patients aged 50 and younger diagnosed with GI cancers.
Participants offered germline testing with a 48-gene multiplex panel and educational resources.
Surveys assessed impacts on genetic knowledge and psychosocial factors before and after testing.
41 of 64 eligible patients enrolled and completed testing, a 64% completion rate.
Pathogenic germline variants identified in 16% of participants, with a median age at diagnosis of 42 years.
Substantial patient engagement demonstrated, indicating interest in universal genetic testing.

Cite This Study

Ludford et al. (2025) studied this question.

synapsesocial.com/papers/69401d472d562116f28f85f7 https://doi.org/10.1158/1557-3265.earlyonsetca25-b025

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Abstract B025: Universal Germline Testing in Young-Onset GI Malignancies: Expanding Access for Underserved Patients

Discussion

Member takes

Implication

Key Points

Cite This Study

Abstract B025: Universal Germline Testing in Young-Onset GI Malignancies: Expanding Access for Underserved Patients

Discussion

Member takes

Implication

Key Points

Cite This Study

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