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December 10, 2025Immunology and Cell BiologyOpen Access

The changing immune landscape of innate‐like T cells and other innate cells throughout life

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Authors

MTMarziyeh TaheriCMChristopher MenneJAJ. L. Anderson

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Overview

Analysis reveals significant phenotypic shifts in immune cells with age, indicating crucial differences in memory T cells and innate cells.

Key Points

  • This research aims to characterize age-related changes in innate and adaptive immune cell populations.
  • Utilized spectral flow cytometry for analysis of immune cells.
  • Investigated chemokine receptors and maturation markers in immune cell subsets.
  • Characterized peripheral blood mononuclear cells across three age groups: newborns, adults aged 20-30, and adults aged over 70.
  • Identified phenotypic changes in innate cells like ILCs, NK cells, and monocytes with age.
  • Notable increase in ILC1 frequency with age, stable ILC2 frequency, and peak ILC3 frequency in young adults.
  • CD57 identified as a universal marker associated with aging in both innate and adaptive immune cells.

Cite This Study

Taheri et al. (2025) studied this question.

synapsesocial.com/papers/69401d472d562116f28f8779https://doi.org/10.1111/imcb.70070
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