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This trial aimed to determine the effectiveness of bupivacaine liposomal injectable suspension on postoperative pain in dogs.

A randomized trial of bupivacaine liposomal injectable suspension shows reduced need for postoperative analgesic rescue in dogs undergoing enucleation

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Randomized trial shows lower pain scores and less need for analgesic rescue in dogs undergoing enucleation with bupivacaine liposomal injection.

This trial aimed to determine the effectiveness of bupivacaine liposomal injectable suspension on postoperative pain in dogs.
Enrolled client-owned dogs undergoing enucleation and assigned to BLIS or saline groups.
Administered hydromorphone and acepromazine preoperatively with propofol induction and isoflurane maintenance.
Applied a peri-incisional injection of BLIS or saline before incision closure.
Conducted pain scoring and algometry at multiple postoperative time points after surgery.
30 dogs completed the study with 15 in each treatment group.
Dogs receiving BLIS had lower odds of requiring rescue analgesia (OR, 0.14).
Dogs receiving BLIS had significantly lower pain scores (OR, 0.38).
No significant impact was observed on mechanical threshold testing.

Cullen et al. (2025) studied this question.

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Randomized trial shows lower pain scores and less need for analgesic rescue in dogs undergoing enucleation with bupivacaine liposomal injection.