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The study aims to identify early changes in adipose tissue-derived miRNAs and their prognostic relevance for type 2 diabetes.

December 9, 2025BMC MedicineOpen Access

Adipose tissue-derived microRNAs as epigenetic modulators of type 2 diabetes

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The study aims to identify early changes in adipose tissue-derived miRNAs and their prognostic relevance for type 2 diabetes.
Multi-omics analyses were conducted on gonadal WAT from diabetes-resistant and diabetes-prone mice.
Correlations were evaluated between metabolic phenotypes and miRNA expression in monozygotic twins discordant for T2D.
Plasma miRNA levels from high-risk females were analyzed in the TÜF study.
Diabetes-prone mice showed reduced insulin sensitivity and ~200 differentially expressed mature miRNAs compared to resistant mice.
227 proteins linked to amino acid metabolism, inflammation, signaling pathways, and insulin resistance were identified.
Differential expression of miRNAs, notably miR-335, was linked to DNA methylation, with altered plasma levels correlating with fasting blood glucose in females.

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This research identifies insulin sensitivity and miRNAs involvement in adipose tissue, suggesting links to type 2 diabetes risk.

Sehgal et al. (2025) studied this question.

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