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This study aims to develop and evaluate Gd-DOTA-based contrast agents for MRI applications.

Highly Inert Gd-DOTA-Based Contrast Agents with a Lipophilic Side Chain for Hepatobiliary and Vascular Magnetic Resonance Imaging

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This study aims to develop and evaluate Gd-DOTA-based contrast agents for MRI applications.
Developed Gd-DOTA complexes with lipophilic side chains.
Measured dissociation half-lives in HCl solution and temperature.
Evaluated hepatic MRI performance in mice and vascular MRI in rabbits.
Gd-L1 and Gd-L2 showed approximately 4 times longer dissociation half-lives than Gd-DOTA.
Gd-L1's hepatic MRI performance matched that of commercial Gd-BOPTA in mice.
Gd-L2 had an r1 value of 14.8 mM-1 s-1 and an 18 min blood elimination half-life in rabbits.

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Study reveals enhanced inertness of novel Gd-DOTA contrast agents in hepatic and vascular MRI, suggesting improved safety and efficacy.

Xu et al. (2025) studied this question.

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