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December 9, 2025American Journal of Lifestyle Medicine

Lifetime Cannabis, Non-Cigarette Tobacco, and Illicit Drug Use and Cardiovascular Disease Among Young and Middle-Aged U.S. Adults

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Authors

JHJoy L. HartMRMaggie K. RichardsonAMAlison C. McLeish

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Overview

Analysis shows higher stroke and coronary heart disease odds in young adults using illicit drugs and e-cigarettes, suggesting new prevention strategies.

Key Points

  • To examine associations between substance use and cardiovascular disease in young and middle-aged U.S. adults.
  • Analyzed data from 2933 adults aged 20-59 years
  • Used National Health and Nutrition Examination Survey (2017-2018)
  • Assessed health care provider diagnosis of cardiovascular disease and substance use
  • Cannabis use associated with higher odds of coronary heart disease (OR = 5.45)
  • Cigar use linked to higher stroke odds (OR = 2.31)
  • E-cigarette use increased odds of high blood pressure (OR = 1.41)
  • Smokeless tobacco use associated with high blood pressure (OR = 1.46)

Cite This Study

Hart et al. (2025) studied this question.

synapsesocial.com/papers/69401d5b2d562116f28f8cbehttps://doi.org/10.1177/15598276251404883
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Association of Cannabis Use With Cardiovascular Outcomes Among US Adults2024 · 182 citations
  2. 2Substance use in adolescence is associated with future cardiovascular disease risk: findings from the national longitudinal study of adolescent to adult health2026
  3. 3Association of Cannabis Use Disorder with Major Adverse Cardiac and Cerebrovascular Events in Older Non-Tobacco Users: A Population-Based Analysis2024 · 9 citations
  4. 4Heavy Lifetime Cannabis Use and Mortality by Sex2024 · 19 citations
  5. 5Cigar, Pipe, and Smokeless Tobacco Use and Cardiovascular Outcomes From Cross Cohort Collaboration2025 · 14 citations