Findings reveal reduced T cell function in a sepsis model, suggesting combinatorial interventions may help reverse immunosuppression.
Our findings provide several layers of T cell dysfunction in sepsis, linking subset redistribution, an exhausted phenotype, mitochondrial impairment, and reduced proliferative capacity, suggesting that future therapeutic interventions aiming to reverse sepsis-induced immunosuppression may require a combinatorial approach.
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Liu et al. (2025) studied this question.
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