What type of study is this?

This is a Case Report study (also classified as: Literature Review).

What question did this study set out to answer?

This case report aims to investigate the uncommon EGFR mutations L747_T751del and K754E in non-small cell lung cancer and their response to treatments.

December 9, 2025Discover OncologyOpen Access

Lung adenocarcinoma harboring uncommon EGFR exon 19 deletion L747T751del and in cis K754E mutation: a case report and literature review

View Full Paper

Ask AI

Bookmark

Authors

RLRunze LiuShandong Tumor Hospital PLPei LiTianjin University of Traditional Chinese Medicine HQHaoming QiuUniversity of Rochester Medical Center

Discussion

Member takes

Implication

Case report reveals limited osimertinib efficacy for leptomeningeal metastasis in metastatic lung adenocarcinoma, indicating challenges with EGFR mutations.

Key Points

This case report aims to investigate the uncommon EGFR mutations L747_T751del and K754E in non-small cell lung cancer and their response to treatments.
Presented a case of a 41-year-old male with metastatic lung adenocarcinoma harboring L747_T751del and K754E mutations.
Administered gefitinib as first-line treatment, then osimertinib due to disease progression.
Evaluated drug binding dynamics between osimertinib and the EGFR mutations in question.
The patient showed disease progression after gefitinib and developed leptomeningeal metastasis.
Osimertinib treatment at both doses (80 mg and 160 mg) was ineffective for controlling intracranial disease.
Simulation indicated reduced binding activity of osimertinib to L747_T751del and K754E compared to other EGFR inhibitors.

Cite This Study

Liu et al. (2025) studied this question.

synapsesocial.com/papers/69401d622d562116f28f8e37 https://doi.org/10.1007/s12672-025-04228-x

View Full Paper

Ask AI

Bookmark

Implication

Case report reveals limited osimertinib efficacy for leptomeningeal metastasis in metastatic lung adenocarcinoma, indicating challenges with EGFR mutations.

Lung adenocarcinoma harboring uncommon EGFR exon 19 deletion L747T751del and in cis K754E mutation: a case report and literature review

Discussion

Member takes

Implication

Key Points

Cite This Study

Lung adenocarcinoma harboring uncommon EGFR exon 19 deletion L747T751del and in cis K754E mutation: a case report and literature review

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider