Macromolecular Differences in the Extracellular Matrix Between Normal and Keratoconus Human Corneas: An Ex Vivo Study

Murilo Bertazzo Peres; Joyce Luciana Covre; Larissa Rigobeli da Rosa; Priscila Cardoso Cristovam; Renan P. Cavalheiro; Yara M. Michelaccci; Mauro Campos

doi:10.1080/02713683.2025.2598813

December 9, 2025Current Eye Research

Macromolecular Differences in the Extracellular Matrix Between Normal and Keratoconus Human Corneas: An Ex Vivo Study

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Key Points

This research aims to examine the differences in the extracellular matrix between normal and keratoconus corneas.
Ex vivo analysis of human corneas
Comparison of macromolecular differences in normal versus keratoconus corneas
Non-collagenous proteins decreased in keratoconus corneas
Levels of decorin, lumican, and KS relatively increased
Decorin was found to be highly glycosylated

Implication

Ex vivo study reveals changes in extracellular matrix proteins in keratoconus corneas, suggesting implications for disease understanding.

Abstract

In corneas with KC, non-collagenous proteins decreased without affecting decorin, lumican, or KS levels, which were relatively increased. In addition, decorin was highly glycosylated.

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Cite This Study

Peres et al. (2025) studied this question.

synapsesocial.com/papers/69401d622d562116f28f8f5b https://doi.org/10.1080/02713683.2025.2598813

View Full Paper

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Macromolecular Differences in the Extracellular Matrix Between Normal and Keratoconus Human Corneas: An Ex Vivo Study

Key Points

Implication

Abstract

Discussion

Cite This Study

Macromolecular Differences in the Extracellular Matrix Between Normal and Keratoconus Human Corneas: An Ex Vivo Study

Key Points

Implication

Abstract

Discussion

Cite This Study

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