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December 9, 2025International Journal of Molecular SciencesOpen Access

Synthesis, Reactions, and Agrochemical Studies of New 4,6-Diaryl-2-hydrazinylnicotinonitriles

В. В. Доценко Vladislav K. Kindop V. K. Kindop Renat G. Achmiz Arina G. Levchenko P. G. Dahno А. З. Темердашев Yu‐Qi Feng Quan‐Fei Zhu Eva S. Daus Igor Yudaev Yu. V. Daus А. В. Аксенов Nicolai A. Aksenov И. В. Аксенова

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Key Points

This research focuses on synthesizing new derivatives of 2-hydrazinylpyridine-3-carbonitrile and evaluates their biological activity as safeners for a herbicide.
Synthesized 4,6-diaryl-2-hydrazinylnicotinonitriles from 4,6-diaryl-2-bromo-3-cyanopyridines and hydrazine hydrate.
Utilized mild conditions (25 °C, dioxane) for high yield synthesis up to quantitative.
Characterized side products from bromination and carbocyclization reactions.
Examined biological activity of new nicotinonitriles as antidotes for 2,4-D herbicide.
Eight synthesized compounds showed notable antidote effect against 2,4-D on sunflower seedlings under laboratory conditions.

Implication

Chemical synthesis of new 2-hydrazinylnicotinonitriles demonstrates significant biological activity against 2,4-D herbicide in sunflower.

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Cite This Study

Доценко et al. (2025) studied this question.

synapsesocial.com/papers/69401d622d562116f28f8fc9 https://doi.org/10.3390/ijms262411874

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