Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 9, 2025Journal of Alzheimer s Disease

Surface-based but not voxel-based morphometry reveals structural abnormalities in individuals with subjective cognitive decline

View Full Paper
Ask AI
Bookmark
Share

Authors

LSLaura SerraSBSabrina BonarotaCDCarlotta Di Domenico

Discussion

Loading...

Member takes

Overview

Observations reveal grey matter and gyrification differences in subjective cognitive decline, indicating early structural changes in Alzheimer's disease.

Key Points

  • The research aims to evaluate grey matter volumes and cortical folding in individuals with subjective cognitive decline compared to those with Alzheimer's disease.
  • 107 participants enrolled: 31 with Alzheimer’s disease, 23 with amnestic mild cognitive impairment, 25 with subjective cognitive decline, 28 healthy subjects.
  • All participants underwent neuropsychological assessments and 3T MRI for imaging.
  • The images were processed using voxel-based and surface-based morphometry methods.
  • VBM indicated atrophic patterns in Alzheimer’s disease and amnestic mild cognitive impairment compared to subjective cognitive decline and healthy subjects.
  • SCD individuals exhibited reduced gyrification and sulcal depth relative to healthy subjects, without volumetric differences.
  • Alzheimer’s patients demonstrated cortical surface abnormalities across all surface-based measures.

Cite This Study

Serra et al. (2025) studied this question.

synapsesocial.com/papers/69401d732d562116f28f93bbhttps://doi.org/10.1177/13872877251400747
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cortical surface-based morphometry in cognitive impairment in sporadic cerebral small vessel disease2024 · 1 citations
  2. 2Clinical predictors of Alzheimer's disease‐like brain atrophy in individuals with memory complaints2024 · 3 citations
  3. 3Neuroanatomical Variations and Their Influence on Cognitive Functions2024
  4. 4Alterations of cortical and subcortical structures in mild cognitive impairment2025
  5. 5Progressive structural alterations in the cerebral small vessel disease with cognitive impairment and vascular dementia2025 · 3 citations