Background Intensive blood pressure (BP) control 94.3 mm Hg, respectively. Compared with usual care, the intervention group reduced cardiovascular outcomes across DBP quartiles with adjusted HRs as follows: Q1: 0.69 (95% CI 0.58 to 0.83, p<0.001), Q2: 0.60 (95% CI 0.50 to 0.71, p < 0.001), Q3: 0.59 (95% CI 0.49 to 0.71, p < 0.001) and Q4: 0.67 (95% CI 0.56 to 0.78, p < 0.001). There was no evidence of interaction between DBP quartiles and groups (p = 0.987). The intervention group had a higher risk of hypotension, which was observed when stratifying by different baseline DBP levels. Intensive BP reduction did not increase the occurrence of injurious falls, syncope or adverse kidney outcomes. Conclusions The intensive BP intervention led by non-physician providers is both effective and safe in reducing CVD and mortality across all baseline DBP groups.
Xie et al. (2025) studied this question.