Copper-catalyzed domino reaction produces diverse 3-acylindolizines in under ball milling, suggesting efficiency in synthesis.
A copper-catalyzed domino reaction of arylidene isoxazolones with 2-(pyridin-2-yl)acetate derivatives under ball-milling conditions has been developed. This protocol provides a rapid and economic approach to constructing a vast variety of biologically important 3-acylindolizines with remarkable functional group tolerance.
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Hu et al. (2025) studied this question.
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