This review demonstrates functionalization and annulation of 1,3-enynes in transition metal catalysis, highlighting diverse outcomes with heterocyclic compounds.
The high reactivity and immediate accessibility of 1,3‐enynes render them versatile foundational units in the synthesis of highly valuable molecular structures, encompassing propargylic, allene, and diene compounds, in addition to carbo‐ and heterocyclic compounds. Transition‐metal catalyzed 1,4‐difunctionalization of 1,3‐enynes represents one of the most powerful approaches that has attracted the attention of chemists. In this review, the functionalization and annulation reactions of 1,3‐enynes under various transition metal‐catalyzed systems are highlighted.
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Doraghi et al. (2025) studied this question.
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