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Assess the chronic hepatotoxic effects of the synthetic dye auramine O using a zebrafish model.

Auramine O, a Synthetic Food Dye, Induces Hepatic Injury by Disrupting NOS2 Signaling, Inflammatory Cytokines, and Metabolic Pathways in an In Vivo Zebrafish Model

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In vivo zebrafish model reveals auramine O exposure increases oxidative stress and disrupts metabolic pathways, indicating potential hepatotoxicity.

Assess the chronic hepatotoxic effects of the synthetic dye auramine O using a zebrafish model.
Zebrafish embryos exposed to auramine O for developmental toxicity assessment.
Adults and larvae were treated with environmentally relevant concentrations for 28 days.
Toxic effects evaluated through oxidative stress, apoptosis, and biochemical analysis.
High-performance liquid chromatography used to quantify auramine O in liver tissue.
Gene expression and histological analyses performed to assess liver injury.
AO exposure caused dose-dependent oxidative stress and apoptosis increases.
Hepatic injury showed significant elevations in reactive oxygen species, lipid peroxidation, and liver enzymes.
Metabolism disruption evident from elevated glucose, cholesterol, and triglyceride levels.
Histopathological changes confirmed liver morphology alterations under AO exposure.

Ramamurthy et al. (2025) studied this question.

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In vivo zebrafish model reveals auramine O exposure increases oxidative stress and disrupts metabolic pathways, indicating potential hepatotoxicity.