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December 9, 2025Current Opinion in ImmunologyOpen Access

Revisiting tryptophan metabolism in cancer: complexity, context, and spatial heterogeneity

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Authors

TXTeng Teng XuMax Planck Institute of BiochemistryCGCamille GuyotMax Planck Institute of BiochemistryPMPeter J. MurrayRoyal College of Surgeons in Ireland

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Implication

Review highlights tryptophan impacts on immune responses in cancer, suggesting spatial profiling may enhance therapeutic strategies.

Key Points

  • The aim is to explore the complex roles of tryptophan metabolism in cancer and its spatial heterogeneity.
  • Review of literature on tryptophan metabolism in cancer
  • Analysis of spatial profiling techniques
  • Discussion of metabolic niches within tumors
  • Tryptophan metabolism impacts immune responses in cancer
  • Tryptophan-depleting enzymes show context-dependent roles
  • Distinct metabolic niches influence local tryptophan availability and downstream signaling

Cite This Study

Xu et al. (2025) studied this question.

synapsesocial.com/papers/69401efa2d562116f28f999ehttps://doi.org/10.1016/j.coi.2025.102706
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