Proteomic profiling reveals transition to periodontitis in gingivitis with inflammatory mechanisms affecting diagnosis and early intervention.
This proteomic profiling reveals complement-to-neutrophil transition from gingivitis to periodontitis, enabling stage-specific diagnosis since current clinical markers cannot distinguish inflammatory mechanisms. The identified protein markers are likely to provide objective molecular evidence for evaluating disease progression, potentially improving early intervention timing and treatment selection compared to traditional clinical measurements alone.
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Hong et al. (2025) studied this question.
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