December 8, 2025AllergyOpen Access

Proteomic and Transcriptomic Signatures of Poor Asthma Symptom Control in the U‐BIOPRED Cohort

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Uncontrolled asthma symptoms were linked to specific proteomic profiles, particularly TWEAKR and CD5L levels.
In 415 asthmatics, higher levels of TWEAKR increased the odds of uncontrolled symptoms, revealing significant implications.
Assessment using LASSO logistic regression and linear regression adjusted for multiple factors identified key protein markers in serum.
Findings suggest potential therapeutic avenues, particularly regarding CD5L as a marker in severe asthma compared to healthy individuals.

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Implication

Cross-sectional analysis showed associations between transcriptomic and proteomic signatures and asthma symptom control, implying potential therapeutic insights.

Cite This Study

Antão et al. (2025) studied this question.

synapsesocial.com/papers/69401f0f2d562116f28fa0f1 https://doi.org/10.1111/all.70178

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Implication

Cross-sectional analysis showed associations between transcriptomic and proteomic signatures and asthma symptom control, implying potential therapeutic insights.

Proteomic and Transcriptomic Signatures of Poor Asthma Symptom Control in the U‐BIOPRED Cohort

Key Points

Discussion

Implication

Cite This Study

Proteomic and Transcriptomic Signatures of Poor Asthma Symptom Control in the U‐BIOPRED Cohort

Key Points

Discussion

Implication

Cite This Study

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